SANT-1 ssium salt PBTZ-169 has improved potency

PBTZ-169 has improved potency

a key regulator of cholesterol metabolism proteins such as PCSK9

4-dihydro-2(1H)-quinolinone (3

Bushnell T

Chemical Name: 4-amino-5-[[1-[[1-[[2-[[1-[[4-amino-1-[[6-amino-1-[[2-[[1-[[1-[[1-[[2-[[1-[(1-carboxy-3-methylsulfanylpropyl)amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-1

SANT-1 ssium salt PBTZ-169 has improved potencySANT 1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT 1 shows IC50s of 20 nM and 30 nM in Shh LIGHT2 and SmoA1 LIGHT2 assay, respectively. Product information CAS Number: 304909 07 7 Molecular Weight: 373. 49 Formula: C23H27N5 Chemical Name: N (4 benzylpiperazin 1 yl) 1 (3,5 dimethyl 1 phenyl 1H pyrazol 4 yl)methanimine Smiles: CC1=C(C=NN2CCN(CC3C=CC=CC=3)CC2)C(C)=NN1C1C=CC=CC=1 InChiKey: FOORCIAZMIWALX JJIBRWJFSA N InChi: InChI=1S