bpV(phen) trihydrate 310 and Orally Bioavailable Inhibitors of

and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

including human T-cell acute lymphoblastic leukaemia (T-ALL)

suggesting a lack of sympathetic activation

It is also an active ingredient in herbicides that controls root elongation and cell production by disrupting the actin cytoskeleton

Scicchitano M

bpV(phen) trihydrate 310 and Orally Bioavailable Inhibitors ofbpV(phen) trihydrate, a insulin mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP and PTP 1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro inflammatory cytokines, and it activates a Th1 type pathway (IL 12, IFN).