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Smiles: C1C2=CC3OCOC=3C=C2OCN1CCOC12CC3CC(C1)CC(C2)C3
confirming that potentiation was due to DNA-PK inhibition
with an IC50 of ~10 μM
37 and 97% TGI
NVP-ADW742 was found to suppresse survival and resistance to chemotherapy in acute myeloid leukemia cells
(S)-Willardiine Catalog No.:M8448-2 Smiles: C1C2=CC3OCOC=3C=C2OCN1CCOC12CC3CC(C1)CC(C2)C3(S) Willardiine is a potent agonist of AMPA kainate receptors with EC50 of 44. 8 uM. IC50 value: 44. 8 uM(EC50) Target: AMPA kainate receptor agonistin vitro: The (S) but not (R) isomers of willardiine and 5 bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1. 8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% . in vivo: In newborn mice (P5,