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RS-127445 administered at 1 to 10 mg/kg with oral significantly inhibits visceral hypersensitivity up to 35 to 74% provoked by restraint stress
Chemical Name: 4-(2-aminoethoxy)-N2
5 nM (PKC-ε)
11)12)2-5(6(4)8)16(10
35)31-26(2
DT2216 60031 RS-127445 administered at 1 toDT2216 is a potent and selective degrader of BCL XL based on PROTAC technology. DT2216 inhibits various BCL XL dependent leukemia and cancer cells but considerably less toxic to platelets. Product information CAS Number: 2365172 42 3 Molecular Weight: 1542. 36 Formula: C77H96ClF3N10O10S4 Chemical Name: (2S,4R) 1 ((S) 2 (7 (4 ((R) 3 ((4 (N (4 (4 ((4' chloro 4,4 dimethyl 3,4,5,6 tetrahydro [1,1' biphenyl] 2 yl)methyl)piperazin 1 yl)benzoyl)sulfamoyl) 2
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