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Formula: C18H24N2OS
InChiKey: SDJNZXKVYYJDDM-UHFFFAOYSA-N
Ceftizoxime sodium (SKF-88373) is third generation cephalosporin effective against Gram-negative and Gram-positive bacteria
1'-biphenyl]-2-carboxylic acid
23(2):165-8
BGB-283 ide Rb3 Formula: C18H24N2OSBGB 283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. BGB 283 potently inhibits BRafV600E activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harboring BRafV600E and EGFR mutation amplification. In BRafV600E colorectal cancer cell lines, BGB 283 effectively inhibits