(R)-(+)-Etomoxir Sodium Salt rtine Maleate Identification and characterization of potent

Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors

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No effects are observed on HeLa cells

DGAT1-IN-3 inhibits human DGAT-1 in CHOK1 cells with an EC50 of 0

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(R)-(+)-Etomoxir Sodium Salt rtine Maleate Identification and characterization of potentEtomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1 (CPT 1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPAR.