APG-115 Size:Contact [email protected] for quotation InChi: InChI=1S/C26H34O11/c1-34-19-10-15(5-6-18(19)30)8-16(12-28)17-9-14(4-3-7-27)11-20(35-2)25(17)37-26-24(33)23(32)22(31)21(13-29)36-26/h3-6

InChi: InChI=1S/C26H34O11/c1-34-19-10-15(5-6-18(19)30)8-16(12-28)17-9-14(4-3-7-27)11-20(35-2)25(17)37-26-24(33)23(32)22(31)21(13-29)36-26/h3-6

Formula: C35H44ClN3O7

Smiles: CN1CCC(CNC2=CC(=NC3=CC(OCCCN4CCCC4)=C(C=C32)OC)C2=CC=C(C)O2)CC1

78(6):1143-1150

Solubility: DMSO : ≥ 125 mg/mL (416

APG-115 Size:Contact [email protected] for quotation InChi: InChI=1S/C26H34O11/c1-34-19-10-15(5-6-18(19)30)8-16(12-28)17-9-14(4-3-7-27)11-20(35-2)25(17)37-26-24(33)23(32)22(31)21(13-29)36-26/h3-6APG 115 (AA 115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3. 8 nM and 1 nM, respectively. APG 115 blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53 dependent manner. Product information CAS Number: 1818393 16 6 Molecular Weight: 642. 59 Formula: C34H38Cl2FN3O4 Chemical Name: 4 {[(3'R,4'S,5'R) 6'' chloro 4' (3 chloro 2 fluorophenyl) 1' ethyl 2'' oxo 1'',2''