22(R)-hydroxy Cholesterol Catalog No.:M22746-C PubMed Central PMCID: PMC4703549

PubMed Central PMCID: PMC4703549

InChiKey: MYRPIYZIAHOECW-SAIXKJTDSA-N

ClH/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6

CHMFL-ABL-053 did not exhibit apparent potency against c-KIT kinase (IC50: over 10000 nM)

binds TRiC subunits and inhibits TRiC activity without perturbation of ATP hydrolysis

22(R)-hydroxy Cholesterol Catalog No.:M22746-C PubMed Central PMCID: PMC4703549EC50: 325 nM 22(R) hydroxy cholesterol is an endogenous agonist for liver X receptors (LXRs). The liver X receptors, LXRR and LXR, together with the farnesoid X receptor, FXR, form a subfamily of these orphan receptors. Recently, it has been reported that LXR and FXR are hormone receptors for oxysterols and bile acids, respectively. In vitro: Previous study found that 22(R) hydroxycholesterol was only found in the adrenals as an intermediate in