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2017 Nov 25
These actions of Mibefradil are consistent with K+ channel inhibition
3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
CAS Number: 85081-18-1
Formula: C11H11F3N2O3
A-317491 sodium salt hydrate thalin 2017 Nov 25A 317491 sodium salt hydrate is a non nucleotide P2X3 and P2X2 3 receptor antagonist, which inhibits calcium flux mediated by the receptors. IC50 value: Target: P2X2 3 receptor It is known that P2X3 and P2X2 3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer
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