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InChi: InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13
Formula: C23H25NO2
Timnodonic acid
Xueqian Gong
Chemical Name: N-[(piperidin-2-yl)methyl]-2
ZNL 02-096 Catalog No.:M11497-2 InChi: InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13ZNL 02 096 is a potent and selective Wee1 Degrader (PROTAC) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon binding ligand Pomalidomide (Cat. No. 6302). ZNL 02 096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT 4 cells in vitro, ZNL 02 096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2 M phase and apoptosis.
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