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2(2):66-84
G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation
giving an explanation of the resistance of PTEN- cells to PLX-4720-induced apoptosis
COC1=CC=CC=C1OC1C(=NC(=NC=1NS(=O)(=O)C1=CC=C(C=C1)C(C)(C)C)C1=NC=CC=N1)OCCO
Smiles: CC1C(=CC=CC=1C1=CN(C)C(=O)C(NC2=CC=C(C=C2)[C@H]2C(=O)N(C)CCN2C)=N1)NC(=O)C1=CC2CCCCC=2S1
MLN-4760 3237 2(2):66-84MLN 4760 is a potent and selective human ACE2 inhibitor (IC50, 0. 44 nM), with excellent selectivity (>5000 fold) versus related enzymes including human testicular ACE (IC50, >100 M) and bovine carboxypeptidase A (CPDA; IC50, 27 M). Product information CAS Number: 305335 31 3 Molecular Weight: 428. 31 Formula: C19H23Cl2N3O4 Chemical Name: (2S) 2 {[(1S) 1 carboxy 2 {1 [(3,5 dichlorophenyl)methyl] 1H imidazol 5 yl}ethyl]amino} 4 methylpentanoic acid