TNF-α-IN-1 220soimperatorin Smiles: CC(C)[C@@H](C(=O)NC1=NC(C)=C(S1)C1=NN=C(C)O1)N1C(=O)NC2=CC=CC=C2C1=O

Smiles: CC(C)[C@@H](C(=O)NC1=NC(C)=C(S1)C1=NN=C(C)O1)N1C(=O)NC2=CC=CC=C2C1=O

Smiles: CC(=O)C1C2C3=C4C(CC=1C)=C(OC)C(=O)C1C4=C(C4=C3C(C(=O)C=2OC)=C(O)C=C4OC)C(=CC=1O)OC

Smiles: COC1=CC2=C(C=C1)N1C=NC(=C1[C@@H]1CCCN1C2=O)C(=O)OCC

activation of caspases and JNK

administration of Defactinib at 25 mg/kg twice a day is selected as the dosing schedule for subsequent therapy experiments

TNF-α-IN-1 220soimperatorin Smiles: CC(C)[C@@H](C(=O)NC1=NC(C)=C(S1)C1=NN=C(C)O1)N1C(=O)NC2=CC=CC=C2C1=OTNF IN 1 is a TNF inhibitor extracted from patent US20030096841A1, compound example I 7. Product information CAS Number: 444287 49 4 Molecular Weight: 363. 75 Formula: C16H14ClN3O5 Chemical Name: 2 chloro N {[2 (2,6 dioxopiperidin 3 yl) 1,3 dioxo 2,3 dihydro 1H isoindol 4 yl]methyl}acetamide Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=C(C=CC=C2CNC(=O)CCl)C1=O InChiKey: XRAYWKDMFVKUTJ UHFFFAOYSA N InChi: InChI=1S C16H14ClN3O5 c17 6 12(22)18 7 8 2 1 3 9