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Bonaventure P
50(8):1876-85
10(1):310-9
Schneider P
In in vitro and in vivo animal experiments
Ethionamide EVD-FMK Bonaventure PEthionamide is a second line antitubercular agent that inhibits mycolic acid synthesis. Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall
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