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and the p70S6K target S6RP are also observed in PTEN-deficient MES-SA human uterine tumor xenografts after treatment with 40 and 50 mg/kg p
InChiKey: ITTRLTNMFYIYPA-UHFFFAOYSA-N
638156-11-3
1418013-75-8
InChi: InChI=1S/C19H15Cl2NO3/c20-13-7-8-14(21)17-16(13)19(25
BSJ-03-123 rescein Diacetate and the p70S6K target S6RPBSJ 03 123 is a Selective Cdk6 degrader. BSJ 03 123 exploits protein interface determinants to achieve proteome wide selectivity for the degradation of cyclin dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.
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