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SAR407899 concentration-dependently inhibits 5-bromodeoxyuridine incorporation into the cells with an IC50 of 5
and 100 mg/kg
Ricietto AP
10 μM and 14
terminally differentiated tissues
Ulixertinib - CAS# 869886-67-9 Catalog No.:M6585-2 SAR407899 concentration-dependently inhibits 5-bromodeoxyuridine incorporationUlixertinib, also known as BVD 523 and VRT752271, CAS No. 869886 67 9, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma induced angiogenesis. Upon oral administration, BVD 523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK mediated signal transduction pathways. This results in the inhibition of ERK dependent tumor cell proliferation and
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