ARRY-520 - CAS# 885060-09-3 azone Maleate and combination therapy resulted in

and combination therapy resulted in the greatest tumor weight reduction

Smiles: CC1NC(=O)NC(C=1C(=O)NC1C=C2C=NNC2=CC=1)C1C=CC(F)=CC=1

Ro 32-0432

Molecular Weight: 437

2-benzothiazol-3-yl)(2

ARRY-520 - CAS# 885060-09-3 azone Maleate and combination therapy resulted inFilanesib, also known as ARRY 520, is a synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY 520 specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic