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1038/jcbfm
thereby abrogating NF-κB binding and p300 recruitment to COX-2 promoter
Smiles: CC1=CC(NC(=O)NCCN2CCC(O)(CC3C=CC=CC=3)CC2)=C2C=CC=CC2=N1
2015 Nov 2
BAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines
Olutasidenib (FT-2102) Size:2mg solid 1038/jcbfmOlutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21. 1 nM, 114 nM for IDH1 R132H, IDH1 R132C, respectively. Product information CAS Number: 1887014 12 1 Molecular Weight: 354. 79 Formula: C18H15ClN4O2 Synonym: FT 2102 Chemical Name: 5 {[1 (6 chloro 2 oxo 1,2 dihydroquinolin 3 yl)ethyl]amino} 1 methyl 6 oxo 1,6 dihydropyridine 2 carbonitrile Smiles:
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