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Delafloxacin demonstrates excellent antibacterial potency and exhibits a low probability for the selection of resistant mutants in MRSA
Chemical Name: (Z)-4-(4-((5-(4
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex
PMID: 30429129
IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR)
A-966492 Size:2mg solid Delafloxacin demonstrates excellent antibacterial potencyA 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast
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