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InChi: InChI=1S/C31H39N5O4S2/c1-19(2)21(4)32-17-23-7-9-24(10-8-23)29(38)34-31-33-18-28(42-31)41-27-16-25(26(40-6)15-20(27)3)30(39)36-13-11-35(12-14-36)22(5)37/h7-10
Smiles: CC1=CC=CC2=C1C=CC1=C2C(=O)C2OCC(C)C=2C1=O
05) on day 1 and by 41
Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA replication
InChiKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N
GCN2-IN-6 L246) InChi: InChI=1S/C31H39N5O4S2/c1-19(2)21(4)32-17-23-7-9-24(10-8-23)29(38)34-31-33-18-28(42-31)41-27-16-25(26(40-6)15-20(27)3)30(39)36-13-11-35(12-14-36)22(5)37/h7-10GCN2 IN 6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in house enzymatic (IC50 of 1. 8 nM) and cellular assays (IC50 of 9. 3 nM). GCN2 IN 6 is also a eIF2 kinase PERK inhibitor with an IC50 of 0. 26 nM (in enzymatic assay) and 230 nM (in cells). Product information CAS Number: 2183470 09 7 Molecular Weight: 485. 29 Formula: C19H12Cl2F2N4O3S Chemical Name: N {3 [2 (2 aminopyrimidin 5 yl)ethynyl] 2,4 difluorophenyl} 2,5
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