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Formula: C15H17FN6O2S
PubMed Central PMCID: PMC4866744
plays a key role in tumor cell proliferation and tumor vascularization
SB-431542 was used at 10 µM concentration in cell culture
including colorectal (HCT-116)
Mitoxantrone - CAS# 65271-80-9 035 Formula: C15H17FN6O2SMitoxantrone, CAS No. 65271 80 9, is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5. 3 M), thus inhibiting cell proliferation. It also inhibits HIV 1 integrase (IC50 = 3. 8 M). Mitoxantrone is exported from cells in an ATP and glutathione dependent manner by multidrug resistance protein 1. 4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis. Product information CAS
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