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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
34337-34347
6(12):e27865
CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules
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CK-1827452 - CAS# 873697-71-3 228 Catalytic site remodelling of theCK 1827452, CAS No. 873697 71 3, is a cardiac specific myosin activator. It is clinically tested for its role in the treatment of left ventricular systolic heart failure. CK 1827452 specifically targets and activates myocardial ATPase and improves energy utilization. CK 1827452 improves systolic function by increasing the systolic ejection duration stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels