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35(3):454-60
1161/HYPERTENSIONAHA
18(23)24)15(12)17(22)16(13)21/h10-11
Smiles: CC(C)OC1C=CC(=CC=1)C1=CNC=C1CN(C)CCN
1256094-72-0
STO-609 - CAS# 52029-86-4 0012 35(3):454-60STO 609, CAS No. 52029 86 4, is a specific inhibitor of the Ca(2+) calmodulin dependent protein kinase kinase. STO 609 inhibits the activities of recombinant CaM KK alpha and CaM KK beta isoforms, with K(i) values of 80 and 15 ng ml, respectively, and also inhibits their autophosphorylation activities. STO 609 is highly selective for CaM KK without any significant effect on the downstream CaM kinases (CaM KI and IV), and the IC(50) value of the
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