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Van Rooyen DM
Kordi Jaz E
VX-745 blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM)
increases haemoglobin S (HbS) affinity for oxygen
thereby arresting the cell cycle in the G1 phase
SGI-1776 oliquiritigenin Van Rooyen DMSGI 1776 is a small molecule pan Pim protein kinase inhibitor with potential antineoplastic activity. Pim kinase inhibitor SGI 1776 binds to and inhibits the activities of Pim 1, 2 and 3, serine threonine kinases, which may result in the interruption of the G1 S phase cell cycle transition, the expression of pro apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be
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