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Pharmacother
InChi: InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H
Smiles: OC(=O)[C@H]1O[C@@H](OC2=C3OC(C4C=C(O)C(O)=CC=4)=C(O)C(=O)C3=C(O)C=C2O)[C@H](O)[C@@H](O)[C@@H]1O
Chemical Name: (3R)-1-{2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]benzoyl}piperidin-3-ol
PubMed PMID: 25533522
Isoginkgetin ker Conjugates 3 PharmacotherIsoginkgetin is a MMP 9 inhibitor, also a Pre mRNA Splicing Inhibitor with IC 50 of 30 uM. target : MMP 9 , Pre mRNA Splicing IC 50: 30 u M (Pre mRNA Splicing)In vitro: Isoginkgetin inhibits HT1080 tumor cell invasion substantially. Isoginkgetin is also quite effective in inhibiting the activities of Akt and MMP 9 in MDA MB 231 breast carcinomas and B16F10 melanoma. Isoginkgetin treatment result in marked decrease in invasion of these cells.
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