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It has improved PK properties relative to UNC0638 and displayed modest brain penetration in vivo
Belda-Iniesta C
Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1
InChi: InChI=1S/C20H17FN6O/c1-12-13(3-2-7-22-12)16-10-24-20(27-11-25-26-19(16)27)23-9-15-14-6-8-28-18(14)5-4-17(15)21/h2-5
CC1C=CC(=CC=1)C(=O)CN1C(=N)SC2CCCCC1=2
YAP-TEAD-IN-1 TFA 64 Racemate It has improved PK propertiesYAP TEAD IN 1 TFA is a potent and competitive peptide inhibitor of YAP TEAD interaction (IC50=25 nM). YAP TEAD IN 1 TFA is a 17mer peptide and shows a higher the binding affinity to TEAD1 (Kd=15 nM) than YAP (50 171) (Kd= 40 nM). Product information CAS Number: 1659305 79 9 Molecular Weight: 2133. 89 Formula: C95H145ClF3N23O23S2 Chemical Name: (4S) 4 ((2S) 1 ((2S) 1 ((2S) 2 ((3S, 6S, 9S, 18S, 21S, 24S, 27S, 30S, 35aS) 18 ((S) 2 ((S) 1 ((S) 2 acetamido
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