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8-trihydroxyanthraquinone
PubMed PMID: 15960526
VX-765 has shown activity in preclinical models of chronic epilepsy
Formula: C11H14ClNO3
MDV-3100 shows dose-independent pharmacokinetics at intravenous and oral doses of 0
VCP 171 KKε-IN-1(compound 1) 8-trihydroxyanthraquinoneAdenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5. 65, binding cooperativity with NECA 0. 68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve injury model of neuropathic pain. Product information CAS Number: 1018830 99 3 Molecular
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