CHMFL-PI3KD-317 Size:Contact [email protected] for quotation dBET6 is well tolerated

dBET6 is well tolerated

inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells

In vivo: In Lewis rats

Neoplastic response of mouse tissues during perinatal age periods and its significance in chemical carcinogenesis

and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses

CHMFL-PI3KD-317 Size:Contact [email protected] for quotation dBET6 is well toleratedCHMFL PI3KD 317 is a highly potent, selective and orally active PI3K inhibitor, with an IC50 of 6 nM, and exhibits over 10 1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3K (IC50, 62. 6 nM), PI3K (IC50, 284 nM), PI3K (IC50, 202. 7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882. 3 nM), VPS34 (IC50, 1801. 7 nM), PI4KIIIA (IC50, 574. 1 nM) and PI4KIIIB (IC50, 300. 2 nM). CHMFL PI3KD 317 inhibits PI3K mediated Akt