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InChiKey: LKZLGMAAKNEGCH-UHFFFAOYSA-N
AEE788 has significantly smaller tumors and complete inhibition of lymph node metastasis
Long-term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death
10 min) dissolved in the bulk perfusion exhibited significantly attenuated responses to caffeine
AKT-IN-VIII decreases cell viability and increases phosphatidylserine (PS) translocation to the outer leaflet of the plasma membrane
CHIR-124 Size:10mg solid InChiKey: LKZLGMAAKNEGCH-UHFFFAOYSA-NCHIR 124 is a quinolone based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0. 0003 micromol L). CHIR 124 interacts synergistically with topoisomerase poisons (e. g., camptothecin or SN 38) in causing growth inhibition in several p53 mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR 124 is a novel
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