Irinotecan hydrochloride trihydrate Catalog No.:M7807-2 and pathogenesis

and pathogenesis

a NAAG peptidase inhibitor

United Arab Emirates) (2010)

9a-octahydro-5

Formula: C13H13ClN2O

Irinotecan hydrochloride trihydrate Catalog No.:M7807-2 and pathogenesisIrinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7 ethyl 10 hydroxy camptothecin (SN 38) by a carboxylesterase converting enzyme. One thousand fold more potent than its parent compound irinotecan, SN 38 inhibits topoisomerase I activity by