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SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM
Formula: C12H7F2NO3S2
NSC-744381
It covalently binds to the cysteine 88 of ubiquitin receptor RPN13 in the 19S regulatory particle and inhibits proteasome function
It binds in the WDR5 peptide-binding pocket and inhibits the catalytic activity of the MLL core complex in vitro
TA 02 - CAS# 1784751-19-4 Catalog No.:M6704-10 SAR407899 is equipotent against humanTA 02, CAS No. 1784751 19 4, is a p38 MAPK inhibitor with IC50 of 20 nM. Product information CAS Number: 1784751 19 4 Molecular Weight: 333. 33 Formula: C20H13F2N3 Synonym: TA 02 TA 02 TA02 Chemical Name: 4 (2 (2 fluorophenyl) 4 (4 fluorophenyl) 1H imidazol 5 yl)pyridine Smiles: FC1C=CC(=CC=1)C1N=C(NC=1C1C=CN=CC=1)C1=CC=CC=C1F InChiKey: QIFJOFNVIVQRNJ UHFFFAOYSA N InChi: InChI=1S C20H13F2N3 c21 15 7 5 13(6 8 15)18 19(14 9 11 23 12 10 14)25 20(24 18)16