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Smiles: CCCCS(=O)C1SC2=NC(=CC(=C2C=1N)C1C=CC=CC=1)C1=CC=CS1
compared with bortezomib
Pyridostatin TFA (1-5 μM
2-off schedule over a period of 21 days
Generating SM(a)RTer compounds for translation termination suppression in A-T and other genetic disorders
Remodelin - Acetyl-transferase NAT10 Inhibitor. CAS# 949912-58-7 Catalog No.:M60187-10S Smiles: CCCCS(=O)C1SC2=NC(=CC(=C2C=1N)C1C=CC=CC=1)C1=CC=CS1Remodelin, CAS No. 949912 58 7, is a novel potent and selective inhibitor of the acetyl transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A C depleted cells and HGPS derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl transferase protein NAT10 was identified as the target of Remodelin