Pay in 4 interest-free payments of $25.00 Learn more
Ships within 48 hours · Estimated delivery Aug 2 - Aug 7
11-17-13-24-20-9-5-4-8-19(17)20)25-14-18(26)15-27-21-10-6-3-7-16(21)12-23/h3-10
ClH/c2-1(3)5-4
27(17):4007-4010
Gouni-Berthold I
VU6000918 is a muscarinic acetylcholine (M4) positive allosteric modulator
MK-2461 1762 11-17-13-24-20-9-5-4-8-19(17)20)25-14-18(26)15-27-21-10-6-3-7-16(21)12-23/h3-10MK 2461 is a novel ATP competitive multitargeted inhibitor of activated c Met with a mean IC50 of 2. 5 nM. IC50 value: 2. 5 nM Target: c Metin vitro: MK 2461 inhibits the kinase activity of human c Met with a mean IC50 of 2. 5 nM in the presence of 50 M ATP. Ron (IC50 = 7 nM) and Flt1 (IC50 = 10 nM) are inhibited by MK 2461 with similar potencies to c Met (IC50 = 2. 5 nM), whereas nine other kinases, including FGFR1, FGFR2, FGFR3, PDGFR, KDR, Flt3,