TAK-659 hydrochloride avendustin B also known as LP-778902

also known as LP-778902

EC50=190 nM)

or the 2OG oxygenase FIH

resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity

Ladostigil (1-10 µM) exerts neuroprotective activities

TAK-659 hydrochloride avendustin B also known as LP-778902TAK 659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3. 2 nM and 4. 6 nM for SYK and FLT3, respectively. TAK 659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). Product information CAS Number: 1952251 28 3 Molecular