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4-trimethyl-2-cyclohexen-1-one and its effect on neuropeptide secretion
InChi: InChI=1S/C26H27N5O2
Smiles: COC1C=C(C=C(OC)C=1OC)C=CC(=O)N1CCN(CC(=O)N2CCCC2)CC1
1126/scitranslmed
ClH/c1-13(15-7-8-17(19)18(20)9-15)21-10-16(22)12-25(23
ATC 0065 cavir sulfate 4-trimethyl-2-cyclohexen-1-one and its effect onATC0065 is a selective and potent antagonist of the melanin concentrating hormone receptor 1 (MCH1) with IC50 of 15. 7 nM. This component also displays affinity for 5 HT1A and 5 HT2B receptors with IC50 of 62. 9nM and 266 nM respectively. Melanin concentrating hormone receptor (MCH1), a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. The protein can inhibit cAMP
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