Lumateperone tosylate y-1-Methoxyaporphine Formula: C20H29N5O3

Formula: C20H29N5O3

representing that inhibition occurs at the transcriptional level

3 mg/mL (263

It is a product of histamine 1-methyltransferase in the pathway of histidine metabolism

2174/1874104501004010057

Lumateperone tosylate y-1-Methoxyaporphine Formula: C20H29N5O3Lumateperone tosylate (ITI 007 tosylate) is a 5 HT2A receptor antagonist (Ki = 0. 54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). IC50 value: 0. 54 nM (Ki, for 5 HT2A receptor )Target: 5 HT2A receptorLumateperone also possesses affinity for the D1 receptor (Ki = 52 nM) and weak affinity for the 1A and 1B adrenergic receptors (Ki = 173 nM at 1) and D4