TH-237A hexiline Maleate 2 mg/kg) leads to a

2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats

57(5):2033-46

CAS Number: 879085-55-9

Ishimata N

2248154-85-8

TH-237A hexiline Maleate 2 mg/kg) leads to aTH 237A is a novel neuroprotective agent, which possess protective properties against amyloid (A) induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to A peptide in the presence of 5 nM TH 237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH 237A .