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ClH/c17-7-2-8-24-11-4-1-3-9-13(11)16(23)19(15(9)22)10-5-6-12(20)18-14(10)21
NCCOC1C=C(N=C(C=1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1
Effect of a sigma-1 receptor agonist
Chemical Name: 7-fluoro-12-methyl-4-oxo-1-azatricyclo[7
and activates apoptotic pathways
DuP-697 rphostin A9 ClH/c17-7-2-8-24-11-4-1-3-9-13(11)16(23)19(15(9)22)10-5-6-12(20)18-14(10)21DuP 697 is a member of the vicinal diaryl heterocycles and a potent, irreversible, selective and orally active COX 2 inhibitor (IC50 of 10 nM and 800 nM for human COX 2 and COX 1, respectively). DuP 697 exerts antiproliferative (IC50 of 42. 8 nM), antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. DuP 697 inhibits prostaglandin synthesis and has anti inflammatory, anticancer and antipyretic effects. Product information CAS Number: