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54(7): 2433-46
leads to dose-dependent tumor growth inhibition (TGI: 76% and 84% for 10 mg/kg and 30 mg/kg)
Chemical Name: 3-[(5-bromopyridin-2-yl)carbamoyl]propanoic acid
N-dimethylhydrazinecarbothioamide
69(1):27-34
ML289 13767 54(7): 2433-46ML289 (VU0463597) is a potent, selective, and CNS penetrant mGlu3 (IC50=0. 66 M) negative allosteric modulator. ML289 displays >15 fold selectivity over mGlu2 and is inactive against mGlu5. Product information CAS Number: 1382481 79 9 Molecular Weight: 349. 42 Formula: C22H23NO3 Synonym: VU0463597 Chemical Name: [(3R) 1 {4 [2 (4 methoxyphenyl)ethynyl]benzoyl}piperidin 3 yl]methanol Smiles: COC1C=CC(=CC=1)C#CC1C=CC(=CC=1)C(=O)N1C[C@H](CO)CCC1 InChiKey:
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