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Chemical Name: MK-8776 S-isomer
attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia
InChi: InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11
ERRgamma could be a novel therapeutic target for prostate cancer treatment
Williams N
CFI-402257 - MPS1/TTK inhibitor. CAS# 1610759-22-2 Catalog No.:M6548-2 Chemical Name: MK-8776 S-isomerCFI 402257, CAS No. 1610759 22 2, is an orally bioavailable inhibitor of monopolar spindle 1 (MPS1 TTK) kinase (IC50 = 1. 7 nM). CFI 402257 is selective for MPS1 TTK over a panel of 262 kinases at a concentration of 1 M. CFI 402257 increases aneuploidy in HCT116 cells when used at concentrations greater than 100 nM. It inhibits cell growth in a panel of breast, ovarian, prostate, pancreatic, lung, and colon cancer cell lines (GI50s = 0. 001 1. 3 M).
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