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2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11
Go6983 was dosed by IV injection to mice bearing B16BL6 tumors at 22 μg per mouse
These data indicates that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2–dependent hematological cancers
It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis
is a potent and selective BET bromodomain inhibitor with Ki of <0
CX-4945 - CK2 (Casein Kinase 2) Inhibitor. CAS# 1009820-21-6 Catalog No.:M60267-2S 2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11CX 4945 (Silmitasertib), CAS No. 1009820 21 6, is a potent, selective and bioavailable CK2 (Casein Kinase 2) Inhibitor with IC50 of 1 nM. It only inhibits 7 of the 238 kinases by more than 90% at concentration of 0. 5 M, which is 500 fold selectivity over CK2. Although in cell free systems CX 4945 inhibits FLT3, PIM1, and CDK1 with IC50 of 35 nM, 46 nM, and 56 nM, respectively, but it is inactive against FLT3, PIM1, and CDK1 in cell based functional
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