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UMI-77 locitral possesses radical scavenging activity

SKU: 56271980473

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Description

possesses radical scavenging activity

Smiles: N[C@@H]1C[C@H]1C1C=CC(=CC=1)C1=CC(O)=CC=C1

Smiles: [2H]C1=C2C(NC(N)=C2[2H])=C([2H])C([2H])=C1[2H]

InChi: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4

AZD6244 was used at 5-10 µM final concentration in vitro and in cellular assays

UMI-77 locitral possesses radical scavenging activityUMI 77 is a selective Mcl 1 inhibitor, which shows high binding affinity to Mcl 1 (IC50=0. 31 M). UMI 77 binds to the BH3 binding groove of Mcl 1 with Ki of 490 nM, showing selectivity over other members of anti apoptotic Bcl 2 members. Product information CAS Number: 518303 20 3 Molecular Weight: 468. 34 Formula: C18H14BrNO5S2 Chemical Name: 2 {[4 (4 bromobenzenesulfonamido) 1 hydroxynaphthalen 2 yl]sulfanyl}acetic acid Smiles:

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