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R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested
Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics
(2002) Proc Natl Acad Sci U S A
1021/ml100293q
+1/p-1/b18-17+
GSK-2981278 - CAS# 1474110-21-8 Catalog No.:M6485-10 R112 also blocked leukotriene C4GSK 2981278, CAS No. 1474110 21 8, is a highly potent and selective inverse agonist of retinoic acid receptor related orphan receptor gamma (ROR gamma). GSK 2981278 is a strong ROR selective inverse agonist that inhibits activation of the il17 promoter. GSK 2981278 robustly inhibits ROR mediated cytokine production at both the mRNA and protein level. GSK 2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK 2981278