AP1189 acetate Size:2mg solid 6 nM) but is essentially

6 nM) but is essentially inactive versus [3H]leukotriene C4 binding in guinea-pig lung homogenates (IC50 values of 19 and 33 microM)

Shearer TW

InChiKey: IYAYHZZWYNXHEQ-UHFFFAOYSA-N

is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2

also known as Y-33075

AP1189 acetate Size:2mg solid 6 nM) but is essentiallyAP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r( ) and Mc3r( ) macrophages. No melanogenesis was induced by AP1189 in B16 F10 melanocytes. In vivo, oral AP1189 elicited anti inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by 3 fold. Product information CAS Number: 959850