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Chemical Name: 2-[7-ethoxy-4-(3-fluorophenyl)-1-oxo-1
smooth muscle and
and increases activation of PKA
and its effectiveness depends on the active metabolite Cycloguanil (IC50=0
Formula: C26H36N6O7S
CJ-42794 Catalog No.:M20871-C Chemical Name: 2-[7-ethoxy-4-(3-fluorophenyl)-1-oxo-1CJ 42794 is a selective prostaglandin E receptor subtype 4(EP4) antagonist, inhibits [3H] PGE2 binding to the human EP4 receptor with a mean pKi of 8. 5, a binding affinity that was at least 200 fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). IC50 value: 8. 5 (pKi ) Target: EP4in vitro: CJ 042794 competitively inhibits PGE2 evoked elevations of intracellular cAMP levels in HEK293 cells
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