Pralatrexate - CAS# 146464-95-1 arin InChi: InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30

InChi: InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30

Formula: C27H18F4N4O3S

149(5):1060-1072

reaching 55% to 75%

hM3 muscarinic receptors and hβ2-adrenoceptor

Pralatrexate - CAS# 146464-95-1 arin InChi: InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30Pralatrexate is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier 1 (RFC 1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC 1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors;