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3)16-8-10-19(11-9-16)33(28
but reduces open probability by > 90% with Ki=0
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex
Klempner SJ
2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15
Simvastatin - CAS# 79902-63-9 Size:Solid 2 mg 3)16-8-10-19(11-9-16)33(28Simvastatin is a competitive inhibitor of HMG CoA reductase. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Simvastatin is marketed under the trade name Zocor and is often prescribed in combination with ezetimibe to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy.
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