HA14-1 - CAS# 65673-63-4 Catalog No.:M10927-2 9-tetrahydro-1H-carbazol-9-yl]propanoic acid

9-tetrahydro-1H-carbazol-9-yl]propanoic acid

11-dien-8-yl]methyl carbamate

nonesterified fattyacids(33%–40%)

generation of ROS

CAS Number: 1217448-46-8

HA14-1 - CAS# 65673-63-4 Catalog No.:M10927-2 9-tetrahydro-1H-carbazol-9-yl]propanoic acidHA14 1 is a potent Bcl 2 inhibitor with potential anticancer activity. HA14 1 induces apoptosis in various human cancer cells. HA14 1 suppressed NF kappaB activation through inhibition of phosphorylation and degradation of IkappaBalpha. This inhibition was correlated with suppression of NF kappaB dependent gene products (c myc, cyclin D1, cox 2, and IAP 1). Additionally, HA14 1 also markedly sustained TNF alpha mediated JNK activation. Product