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Smiles: OC(=O)C1=CC=CC=C1C(=O)NC1C=CC(=CC=1)C1C=CC=CC=1
It also inhibits the proliferation of U87MG
including polygonal cell shapes
InChi: InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4
2007 Jan 15
E-7449 - CAS# 1140964-99-3 0290 Smiles: OC(=O)C1=CC=CC=C1C(=O)NC1C=CC(=CC=1)C1C=CC=CC=1E 7449, also known as 2X 121, CAS No. 1140964 99 3, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E 7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes
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