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Modulation of nuclear factor-κB signaling and reduction of neural tube defects by quercetin-3-glucoside in embryos of diabetic mice
US 20110201622 A1
but not 24 h
Solubility: DMSO 85 mg/mL (198
16-13+/t24-
GN25 Catalog No.:M22429-C Modulation of nuclear factor-κB signalingGN25 is a novel inhibitor of Snail p53 binding . P53 is a tumor suppressor that induces cell death, growth arrest and suppresses metastasis, and is often mutated or suppressed by various kinds of cellular signaling pathways in human cancers. In K Ras activated cancer cells, oncogenic K Ras inhibits the p53 function through induction of Snail, which binds to and eliminates p53 through exocytosis. The specific inhibitor against p53 Snail binding would