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K858 - a novel inhibitor of mitotic kinesin Eg5 and antitumor agent.. CAS# 72926-24-0 297 Epub 2014 Aug 4

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Description

Epub 2014 Aug 4

WHI-P154 (4 μM) moderately sensitizes ABCB1-overexpressing KB-C2 cells to its substrates whereas shows no sensitizing effect on ABCC1-

Treatment with AMD3100 at any concentration (10

WWL113 serves as a very useful chemical tool to pharmacologically validate Ces3 as a new therapeutic target

Chapurlat RD

K858 - a novel inhibitor of mitotic kinesin Eg5 and antitumor agent.. CAS# 72926-24-0 297 Epub 2014 Aug 4K858, CAS No. 72926 24 0, is a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. K858 blocked centrosome separation, activated the spindle checkpoint, and induced mitotic arrest in cells accompanied by the formation of monopolar spindles. Long term continuous treatment of cancer cells with K858 resulted in antiproliferative effects through the induction of mitotic cell death, and polyploidization followed

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